Biomaterials and Drug Delivery
The field of biomaterials focuses on design of materials that integrate with living tissues in a way that diagnoses, treats, replaces, or augments tissue function. Drug Delivery involves the design of materials that improve the performance of pharmaceutics by maximizing on-target therapeutic effects and limiting toxicity-causing side-effects. Areas of Biomaterials and Drug Delivery include: tissue engineering/regenerative medicine, orthopedics, medical implants, biosensors, controlled drug release, nanomedicine, targeted and stimuli-responsive delivery, and immunomodulation. These interdisciplinary fields are rapidly growing and evolving in response to new innovations in biotechnology and the clinical need for “smarter” therapies.
Dave Puleo: Regenerative Biomaterials Lab
Adam Smith: Smith Lab
Thomas Werfel: Interdisciplinary NanoBioSciences Lab
The biomedical microdevices area leverages microscale structures and phenomena to create novel instrumentation for research in biology and medicine. Microscale phenomena give researchers a new set of tools for performing experiments that are either impossible or impractical with traditional technology. For example, researchers in the Biomedical Engineering Department at the University of Mississippi use microdevices to perform high throughput screening of drug candidates using only picoliters per sample and create complex oxygen landscapes within cell cultures.
Glenn Walker: Walker Lab
Researchers at the University of Mississippi are primarily focused on developing multi-omics approaches for biomarker and drug discovery in immunological diseases and cancer. This goal is accomplished by evaluating various immunomodulators in clinical trials and assessing their effect on key inflammatory pathways. Machine learning and computational approaches are applied to evaluate the wiring of major immune axes and define an immune modulation spectrum across multiple diseases to facilitate drug discovery and repurposing.
Ana Pavel: Computational Biology Lab
Molecular Biophysics is a rapidly evolving interdisciplinary area of research at the interface of biology, chemistry, physics, and engineering. We seek to understand the mechanics of biology from the single molecule to complex system levels, such as how biomolecules are made and how different parts of a cell move and function. Using novel approaches to better understand life at the molecular level will be pivotal in discovering the mechanisms of disease and thus developing more targeted therapeutics. Researchers at the University of Mississippi investigate the biophysics of cytoskeletal hierarchy (systems that include molecular motors, proteins, microtubules, actin, etc.) and the implications of their synergy in vital life processes such as cell division and motility using a biophysical technique called optical tweezers.
Nikki Reinemann: Molecular Biophysics and Engineering Lab
Biomechanics is simply the study of mechanical laws relating to the movement or structure of living organisms. Neuro-Biomechanics is an attempt to understand how muscles, sense organs, motor pattern generators, and the brain interact to produce coordinated movement, not only in complex terrain but also when confronted with unexpected perturbations. For example, research in Neuro-Biomechanics aims to characterize human pathologies which adversely impact the ability to walk or maintain postural stability.
Dwight Waddell: Waddell Lab